Effect
What Noxious Bloom does
Venom kills burst, poisoning nearby foes for 150%.
Noxious Bloom is a legendary chest item that raises Venom Burst for your whole build. It lasts for the rest of the run. One copy is all it needs; extra copies do nothing.
Source
How to get Noxious Bloom
Chest items drop from treasure chests out in the wilds — spend gold to open one, and each chest costs more than the last. Rarer items are rarer drops, so Luck (from Fortune or the Censer) makes a legendary pull more likely. On every floor’s plaza the Wishing Well grants the exact item you name once per floor: the surest way to complete a build around Noxious Bloom.
Fit
Works with every skill
Noxious Bloom is not tied to a skill, which makes it a safe pick for any run. General items like this carry a build through the early floors while the skill-specific legendaries wait for the Wishing Well.
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